BELOW ARE MANY OF THE SCIENTIFIC PAPERS THAT WE’VE DRAWN ON TO DEVELOP OUR NATURAL PRODUCTS:

Inflammation and Ageing

Ahn KS and Aggarwal BB “Transcription Factor NF- κB: A Sensor for Smoke and Stress Signals” (2005) 1056 Annals of the New York Academy of Sciences 218.

Alov P and others “Computational Studies of Free Radical-Scavenging Properties of Phenolic Compounds” (2015) 15(2) Current Topics in Medicinal Chemistry 85.

Baylis D and others “Understanding How We Age: Insights into Inflammaging” (2013) 2 Longevity and Healthspan.

Berg D and others “Redox Imbalance” (2004) 318 Cell and Tissue Research 201.

Bertram C and Hass, R “Cellular Responses to Reactive Oxygen Species-induced DNA Damage and Aging” (2008) 389 Biological Chemistry.

Borut P and others “Review Aritcle Achieving the Balance Between ROS and Antioxidants; When to Use Synthetic Antioxidants” (2013) Oxidative Medicine and Cellular Longevity.

Calcada D and others “The Role of Low-grade Inflammation and Metabolic Flexibility in Aging and Nutritional Modulation Thereof; a systems biology approach” (2014) Mechanisms of Ageing and Development 138.

Campisi J “Aging, Cellular Sensescence and Cancer” (2013) 75 Annual Review of Physiology 699.

Candore G and others “Inflammation, Genetic Background and Longevity” (2010) 11 Bogenrontology 565.

Cannizzo E and others “Oxidative Stress, Inflamm-aging and Immunosenscence” (2011) 74 Journal of Proteomics 2313.

Castellani C and others “Systems Medicine of Inflammaging” (2016) 17.3 Breifings Bioinformatics 527.

Chung H “Molecular inflammation: Underpinnings of Aging and Age-related diseases” (2009) 8 Ageing Research Reviews 18.

Coates P “In brief: Cell Senescence” (2013) 230 The Journal of Pathology 239.

Davies K “An Overview of Oxidative Stress” (2000) 50 IUBMB Life 241.

Ershler W “A Grippling Reality; Oxidative Stress, Inflammation and the Pathway to Frailty” (2007) 103.1 Journal of Applied Physiology.

Fang Y and others. “Free Radicals, Antioxidants, and Nutrition” (2002) 18 Nutrition 872.

Fogarasi E and others “Is the Oxidative Stress Really a Disease?” (2016) 62 Acta Medica Marisiensis.

Franceschi C and Campisi J “Chronic Inflammation (inflammaging) and its potential contribution to age associated diseases.” 69 The Journals of Gerontology S4.

Frasca D and Blomberg B “Inflammaging decreases adaptive and innate immune responses in mice and humans” (2016) 17 Biogerontology 7.

Freitas-Simoes TM and others “Nutrients, foods, dietary patterns and telemore length: update of epidemiological studies” 65 Metabolism 406.

Fulle S and others “The contribution of reactive oxygen species to sarcopenia and muscle ageing” (2004) 39 Experimental Gerontology 17.

Kirkwood T and Kowald A “The free-radical theory of ageing- odler, wiser and still alive” (2012) 34 BioEssays 692.

Larbi A and others. “Aging of the Immune System as a prognostic factor for human longevity” (2008) 23 Physiology 64.

Lee J and others. “Reactive oxygen species, aging and antioxidative nutraceuticals” (2004) 3 Comprehensive Reviews in Food Science and Food Safety.

Liu Y and others “Mitochondrial free radical theory of aging; who moved my premise?” (2014) 14 Geriatrics & Gerentology International 740.

Lushchak V “Free radical, reactive oxygen species, oxidative stress and its classifciation” (2014) 224 Chemico-Biological Interactions. 164.

McCord J “The evolution of free radicials and oxidative stress” (2000) 108 The Amercian Journal of Medicine 652.

Muñoz A and Costa M “Nutritionally Mediated Oxidative Stress and Inflammation.” (2013) Oxidative Medicine and Cellular Longevity.

Muriach M and others “Diabetes and the Brain: oxidative stress, inflammation and autophagy” (2014) Oxidative Medicine and Cellular Longevity.

Petersen K and Smith C “Ageing-associated oxidative stress and inflammation are alleviated by products from grapes.” (2016) Oxidative Medicine and Cellular Longevity.

Pryor W and others “Free radicial biology and medicine: it’s a gas man!” (2006) 291 AJP: Regulatory, Integrative and Comparative Physiology.

Rafie N and others “Dietary patterns, food groups and telomere length: a systematic review of current studies” (2017) Eur J Clin Nutr.

Rustom A “The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases” (2016) Open Biology.

Seals D and others. “Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity” (2016) 549 The Journal of Physiology 2001.

Soysal P and others “Inflammation and frailty in the elderly: A systematic review and meta-analysis.” (2016) 31 Ageing Res Review 1.

Speakman J and Selman C “The free-radical damage theory: Accumulating evdience against a simple link of oxidative stress to ageing and lifespan” (2011) 33 Bio Essays 255.

Sosa V and others “Oxidative stress and cancer: an overview” (2013) 12 Ageing Research Review 376.

Van Deursen J “ The role of senescent cells in ageing” (2014) 509 Nature 439.

Viña J and others “Theories of ageing” (2007) 59 IUBMB 249.

Zhang J and others “Ageing and the telomere connection: an intimate relationship with inflammation” (2016) 25 Ageing Research Reviews 55.

Cancer

Aggarwal B and Gehlot P “Inflammation and cancer; how friendly is the relationship for cancer patients” (2009) 9 Current Opinion in Pharmacology 351.

Amir K and others “Chronic inflammation predisposing to cancer metastasis: lesson learned from chronically embedded foreign body in a duodenal diverticulum” (2014) 45 Journal of Gastronintestinal Cancer 136.

Belpomme D and others “The multitude and diversity of environment carcinogens” (2007) 105 Environmental Research 414.

Björn L and others “Achalasia and Esophageal Cancer: Incidence, Prevalence and Prognosis” (2001) 25 World Journal of Surgery 745.

Borrello M and others “Inflammation and cancer: the oncogene-drvien connection” 267 Cancer Letters 262.

Bosch FX and others “The causal realtion between human papillmavirus and cervical cancer” (2002) 55 J Clin Panthol 244.

Coffelt S and de Visser K “Cancer inflammation lights the way to metatasis” (2014) 507 Nature 48.

Cross F and Roberts J “Oncogenes and cell proliferation” (2001) 11 Current Opinion in Genetics and Development 11.

Doll R “Tobacco: A Medical History. Journal of Urban Health” (1999) 76 Bulletin of the New York Academy of Medicine.

Doll R and Hill AB “The mortality of doctors in relation to their smoking habits: A preliminary report.” (1954) Br Med J 1451.

Dolgin E “Cancer vaccines: Material Breach” (2013) 504 Nature S16.

Faguet G “A brief history of cancer: age old milestones underlying our current knowledge database” (2015) 136 International Journal of Cancer 2022.

Ferguson L “Chronic inflammation and mutagensis” (2010) 690 Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 3.

Ferlay J and others “Cancer incidence and mortalitiy worldwide: sources, methods and major patterns in GLOBOCAN 2012.” (2015) 136 International Journal of Cancer 359.

Garrett M “Oncogenes and cell proliferation” (2005) 15 Current Opinion in Genetics and Development 1.

Gilbert C and Slingerland J “Cytokines, Obesity and Cancer: New insights on mechanisms linking obesity to cancer risk and progression” (2013) 64 Annual Review of Medicine 45.

Goodwin P and Stambolic V “Impact of the Obesity Epidemic on Cancer” (2013) 66 Annual Review of Medicine 281.

Hajdu SI “A note from history: Landmarks in hisotry of cancer” (2011) 117 Cancer 1097.

Hoenerhoff M “Inflammation and cancer; Partners in Crime” (2015) 206 The Veterinary Journal 1.

Iyengar N and others “Obesity and Cancer: Local and Systemic Mechanisms” (2015) 66 Annual Review of Medicine 297.

Jamrozik E and others “Absestos-related disease” (2011) 41 Internal Medicine Journal.

Johnson WM “Tobacco Smoking, a Clinical Study” (1929) 93 J.A.M.A. 665.

Katherine E and others “Unhealthy diests; a common soil for the association of metabolic syndrome and cancer” (2014) 46 Endocrine 39.

Kim M and others “Prevention of Hepatocellular Carcinoma: Beyond Hepatitis B Vaccination” (2015) 42 Seminars in Oncology 316.

Lee C and others “Obesity, adipokines and cancer: an update” (2015) 83 Clinical Endocrinology 147.

Lukasz D and Ewa M “Lifestyle Modifications and Colorectal Cancer (2014). 10 Current Colorectal Cancer Reports 45.

Mangesh A and Cuzick J “The role of aspirin in cancer prevention” (2013) 15 Curr Oncol Rep 533.

Manuel J “Environment, Genes and Cancer” (1996) 104 Environmental Health Perspectives 256.

Mantovani A and others “Cancer-related inflammation” (2008) 254 Nature 436.

Pinzani M and others “Liver cirrhosis” (2011) 25 Best Practice & Research Clinical Gastroenterology 281.

Raposo TP and others “Inflammation and cancer; till death tears them apart” (2015) 205 The Veterinary Journal 161.

Read S and Douglas M “Virus induced inflammation and cancer development” (2014) 345 Cancer Letters 174.

Rothwell P and others “Short-term effect of daily aspirin on cancer incidence, mortality and non vascular death; analysis of the time-course of the risks and benefits in 51 randomised controlled trials” (2012) 379 Lancet 1602.

Schrek R and others “Tobacco Smoking as an Etiologic Factor in Disease” (1950) 10 Cancer Res 49.

Seyfried T and others “Cancer as a metabolic disease: implications for novel therapeutics” (2014) 35 Carcinogensis 515.

Steenland K and Ward E “Silica: a long carcinogen” (2014) 64 Cancer Journal for Clinicians 63

Takeo I “NSAIDS and colorectal cancer prevetion” (2009) 44 J Gastroenterol.

Taylor Brian and Waterhouse AH “Prognosis for Bronchial Carcinoma” (1950) 5 Thorax 257.

Venerito M and others “Helicobacter Pylori and Gastrointestinal Malignancies” (2015) 20 Helicobacter 36.

Weiss R and Vogt P “100 years of Rous Sarcoma Virus” (2011) 208 The Journal of Experimental Medicine 2351.

Weitzel J and others “Genetics, genomics and cancer risk assesssment” (2011) 61 Cancer Journal for Clinicians 327.

Wilson G and George J “Physical and Chemical Insults induce inflammations and gastrointestinal cancers” 345 Cancer Letters 190.

“Cancer. Solving an age-old problem” (2012) 483 Nature.

Heart disease and stroke

Antonopoulos A and others “Statins as Anti-Inflammatory Agents in Atherogensis: Molecular Mechanisms and Lessons from the Recent Clinical Trials” (2012) 18 Current Pharmaceutical Design 1519.

Blaha M and Martin S “ How do statins work?” (2013) 62 Journal of the American College of Cardiology 2392.

Cheryl L and Fernando E “Inflammation and Therapy for Hypertension” (2010) 12 Current Hypertension Repotrs 233.

Falk E “Pathogenesis of atherosclerosis” (2006) 47 Journal of the American College of Cardiology.

Grundy S “Statins for All?” (2014) 114 The American Journal of Cardiology 1443.

Ikonomidis I “Inflammatory markers in coronary artery disease” (2012) 38.5 BioFactors 320.

Jukema J and others “The Controversies of Statin Therapy” (2012) 60 American Journal of Cardiology.

Kang J and others “Imaging the renin-angiotensin system: An important target of anti-hypertensive therapy” (2006) 58 Advanced Drug Delivery Review 824.

Kinlay S and Selwyn A “Effect of statins on inflammation in patients with acute and chronic coronary syndromes” (2003) 91 The American Journal of Cardiology 9.

Libby P and others “Inflammation in artherosclerosis; from pathophysiology to practice” (2009) 54 Journal of the American College of Cardiology.

Libby P “History of Discovery-Inflammation in Atherosclerosis” (2012) 32 Arterioscler Throm Vasc Biol 2045.

Mahesh P and Michael B “Inflammation and Atherosclerosis: Disease Modulating Therapies” (2013) 15 Current Treatment Options in Cardiovascular Medicine 681.

Marvar P and others “The central nervous system and inflammation in hypertension” (2011) 11 Current Opinion in Pharmacology 156.

Matsuura E and others “Oxidation of LDL and its clinical implications” (2008) 7 Autoimmunity Reviews 558.

Montecucco F and Mach F “Statins, ACE inhibitors and ARBs in cardiovascular disease” (2009) 23 Best Practice and Research Clinical Endocrinology and Metabolism 389.

Nilsson J and others “Atheroprotective immunity and cardiovascular disease: therapeutic opportunities and challenges” (2015) 278 Journal of Internal Medicine 507.

Paolo C and others “CRP and the risk of atherosclerotic events” (2009) 31 Seminars in Immunopathology 79.

Pickering T “Stress, Inflammation, and Hypertension” (2007) 9 Journal of Clinical Hypertension 569.

Shah P and others “Vaccine for Atherosclerosis” (2014) 64 Journal of the Amercian College of Cardiology 2779.

Suzuki Y and others “Inflammation and angiotensin II” (2003) 35 The International Journal of Biochemistry and Cell Biology 881.

Tousoulis D and others “Innate and Adaptive Inflammation as a Therapeutic Target in Vascular Disease” (2014) 63 Journal of the American College of Cardiology 2491.

Weintraub H “Identifying the vulnerable patients with rupture-prone plaque” (2008) 101 American Journal of Cardiology 3F

Wick G and Grundtman C “Inflammation and atherosclerosis” (2012) Spriger Verlay/ Wein.

Dementia

Ader R “On the development of pyschoneuroimmunology” (2000) 405 European Journal of Pharmacology 161.

Bahramsoltani R and others “Phytochemical constituents as future antidepressants; a comprehensive review” (2015) 26 Reviews in the Neurosciences 710.

Brown G and Vilalta A “How microglia kill neurons” (2015) 1628 Brian Research 288.

Butchart J “Systemic inflammation and Alzheimer’s disease” (2011) 39 Biochemical Society Transactions 898.

Dening T and Sandilyan M “Dementia: definitions and types” (2015) 29 Nursing Standard 37

Desai A “Dieatary Polyphenols as Potential Remedy for Dementia” (2016) 12 Adv Neurobiol 41.

Felix D and others “The Blood-Brain Barrier” (2013) 8 Journal of Neuroimmune Pharmacology 763.

Hayley S and others “Inflammation and the microbiome: implications for depressive disorders” (2016) 29 Current Opinion in Pharmacology 42.

Holmes C “Review: Systematic Inflammation and Alzheimer’s disease” (2013) 39 Neuropathy and Applied Neurobiology 51.

Hu Z and others “Inflammation: a bridge between postoperative cognitive dysfunction and Alzheimer’s disease” (2010) 74 Medical Hypotheses 722.

Janssen D and others “A psychoneuroimmunological review on cytokines involved in antidepressant treatment response” (2010) 25 Human Psychopharmacology: Clinical and Experimental 201.

Johnston H “Assessing the contribution of inflammation in models of Alzheimer’s disease” (2011) 39 Biochemical Society Transactions 886.

Keaney J and Campbell M “The dynamic blood-brain barrier” (2015) 282 Febs Journal 4067.

Kettenmann H and others “Physiology of Microglia” (2011) 91 Physiological Review 461.

Koyama A and others “Inflammation and Risk of Dementia: A Meta-Analysis of Observational Studies” (2012) 8 Alzheimer’s and Dementia.

Leonard B “Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants” (2014) 48 Progress in Neuro-Pyschopahrmcology 261.

Leonard B and Myint A “The psychoneuroimmunology of depression” (2009) 24 Human Psychopharmacology: Clinical and Experimental 165.

Libro R and others “Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview” (2016) 21 Molecules 518.

McGeer PL and others “Inflammation, Antiinflammatory Agents and Alzheimer’s Disease: the Last 22 years” (2016) 54 J Alzheimers Dis 853.

Mendiola-Precoma J and others “Therapies for Prevention and Treatment of Alzheimer’s Disease” (2016) BioMed Research International.

Miller D and O’Callaghan J “Depression, cytokines and glial function” (2005). 54 Metabolism 33.

O’Donovan A and others “Suicidal ideation is associated with elevated inflammation in patients with mahor depressive disorder” (2013) 30 Depresseion and Anxiety 307.

Pathak L and others “A Natural polyphenols in the management of major depression” (2013) 22 Expert Opin Investig Drugs 863.

Phani S and others “Neurodegeneration and inflammation in Parkinson’s disease” (2012) 18 Parkinsonism & Related Disorders S209.

Schott J “Infection, inflammation and Alzheimer’s disease” (2015) 22 European Journal of Neurology 1503.

Sezgin Z and Dincer Y “Alzheimer’s disease and epigeetic diet” (2014) 78 Neurochemistry International 105.

Shua-Haim J and Gross J “Alzheimer’s Syndrome, Not Alzheimer’s Disease” (1996) 44 Journal of American Geriatrics Society.

Simone M and Tan Z. “The role of inflammation in the pathogenesis of delrium and dementia in older adults” (2011) 17 CNS: Neuroscience and Therapeutics.

Song C and Wang H “Cytokines mediated inflammation and decreased neurogensis in animal models of depression” (2011) 35 Progress in Neiro-Pyschopharmacology and Biological Psychiatry 760.

Su K “Nurition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon induced depression” (2015) 5 BioMedicine.

Wilson C and others “Cytokines and Cognititon: The Case for a Head to Tow Inflammatory Paradigm” (2002) 50 Journal of Amercian Geriatrics Society.

Turmeric

Aggarwal BB and Sung B “Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.” (2009) 30 Trends Pharmacol Sci 85.

Aggarwal B and Harikumar K “Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmunue and neoplastic diseases” (2009) 41 The International Journal of Biochemistry & Cell Biology 40.

Ahmed T and Gilani A “Therapeutic Potential of Turmeric in Alzheimer’s Disease: Curcumin or Curcumnoids?” (2014) 28 Phytotherapy Research 517.

Bernard U and Robert B “Is Curcumin a Chemopreventive Agent for Colorectal Cancer?” (2016) 12 Current Colorectal Cancer Reports 35.

Bisht S and Maitra A “Systemic delivery of curcumin: 21st century solution for an ancient conundrum” (2009) 6 Curr Drug Discov Technol 192.

Brietzke E and others “Is there a role for curcimin in the treatment of bipolar disorder?” (2013) 80 Medical Hypotheses 606

Chandran B and Goel A “A randomised, pilot study to assess the efficacy and safety of curcumin in patients with activeheumatoid arthritis” (2012) 11 Phytother Res 1719.

Chang Y and others “GRP78 mediates the therapeutic efficacy of curcumin on colon cancer” (2014) 36 Tumor Biology 633.

Churches Q and others “Naturally occuring polyphenolic inhibitors of amyloid beta aggregation” (2014) 24 Bioorganis and Medicinal Chemistry Letters 3108.

Mazur A and Morand C “Dietary curcumin inhibits athersclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration” (2012) 56 Molecular Nutrition and Food Research 1270.

Duke J “Tumeric, the Queen of the COX-2 inhibitors” (2007) Alternative and Complementary Therapies.

Esatbeyoglu T and others “Curcumin: From Molecule to Biological function” (2012) 51 Angewandte Chemie International Edition 5308.

Gescher A “Multitargeting by turmeric, the golden spice: from ktichen to clinic” (2013) 57 Molecular Nutrition and Food Research 1510.

Gupta SC and others “Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials” (2013) 15 The AAPS Journal 195.

Grynkiewicz G and Slifirski P “Curcumin and curcuminoids in quest for medicinal status” (2012) Acta Biochemica Polonica.

Hiroshi I “Potent preventive action of curcimin on radiation induced initiation of mammart tumorigenesis in rats” (200) 21 M.N.M.Y.T.H.K.

Howes M and Perry E “The Role of Phytochemicals in the Treatment and Prevention of Dementia” (2012) 28 Drugs & Aging 439.

Jaggi L “Turmeric, Curcumin and Our Life: A Review” (2012) 1 Pharmacol. Life Sci 11. Jiang H and others “Anti-depressant-like effects of curcumin in chronic mild stress of rats: involvement of anti-inflammatory actions” (2013) 47 Progress in Neuro-Psychopharmacology and Biological Psychiatry 33.

Kalani A and others “Epigenetic impact of curcumin on stroke prevention” (2015) 30 Metabolic Brain Disease 427.

Kapakos G and others “Cardiovascular protection by curcumin: molecular aspects.” (2012) 49 Indian J Biochem Biophys 306.

Kumar A and others “Curcumin Resource Database” (2015) The Journal of Biological Databases and Curation 1.

Lee WH and others “Curcumin and its Derivative: Their application in neuropharamcology and neuroscience in the 21st century” (2013) 11 Current Neuropharmacology 338.

Maiti K and others “Curcumin-phospholipid complex: preparation, therapeuti evaluation and pharmacokinetic study in rats” (2007) 330 Interantional Journal of Pharmaceutics 155.

Manish J and others “ Improvement of Bioavailiability and Anti Inflammatory Potential of Curcumin in Combination with Eme Oil” (2014) Inflammation 2139.

Mario PM “Curcumin and Health” (2016) 21 Molecules 264.

Mazzanti G and Di Giacomo S “Curcumin and Resveratrol in the Management of Cognitive Disorders: What Is the Clinical Evidence?” (2016) 21 Molecules 1243.

Mishra S and Palanivelu K “The Effect of Curcumin (turmeric) on Alzheimer’s Disease: An Overview” (2008) 11 Annals of Indian Academy of Neurology 13.

Queen BL and Tollefsbol TO “Polyphenols and Aging” (2010) 3 Current Aging Science 34.

Prasad S and others “Curcumin, a component of golden spiceL From beside to bench and back” (2014) 32 Biotechnology Advances 1053.

Ravindran PN and others “Tumeric: The genus Curcuma” (2007) Medicinal and Aromatic Plants – Industrial Profiles CRC Press.

Reddi P “A Touch of Turmeric: Examining an Ayurvedic Treasure” (2013) 3 Advances in Anthropology 91.

Shen L and others “How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies” (2016) Scientific Reports.

Shishodia S and others “Role of Curcumin in Cancer Therapy” (2007) 31 Current Problems in Cancer 243.

Sikora E and others. “Curcumin, inflammation, ageing and age-related diseases” (2010) Immunity & Ageing 3.

Subash C and others “Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials” (2013) 15 AAPA J 195.

Sun A and others “Botanical Phenolics and Brain Health” (2008) 10 NeuroMolecular Medicine 259.

Vaughn A and others “Effects of Turmeric (Curcuma Ionga) on Skin Health: A Systematic Review of the Clinical Evidence” (2016) 30 Phytotherapy Researach 1243. Willcox DC and others “Healthy Aging diets other than the Mediterranean: A Focus on the Okinawan Diet” (2014) 136 Mechanisms of Aging and Development 148.

Zingg J and Meydani M “Curcumin and aging” (2013) 39 BioFactors 133.

Zingg J and Meydani M “Molecular mechanisms of curcumin action: Gene Expression” (2013) 39 BioFactors 37.

Zingg J and Meydani M “Curcumin in various cancers” (2013) 39 BioFactors 56.

Zingg J and Meydani M “Curcumin in inflammatory diseases” (2013) 39 BioFactors 69.

Zingg J and Meydani M “Curcumin and obesity” (2013) 39 BioFactors 78.

Zhang D and others “Curcumin and Diabetes: A systematic Review” (2013) Evidence-Based Complementary and Alternative Medicine.

Grape seeds and skin

Akaberi M and Hosseinzadeh H “Grapes (Vitis vinifers) as a Potential Candidate for the Therapy of the Metabolic Syndrome” (2016) 30 Phytotherapy Research 540.

Alarcón de la Lastra C and Villegas I “Resveratrol as an anti inflammatory and anti aging agent: Mechnaisms and clinical implications” (2005) 49 Molecular Nutrition and Food Research 405.

Ali K and others “Metabolic constituents of grapevine and grape-derived products” (2010) 9 Phytochemistry Reviews 357.

Anastasiadi M and others “Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties” (2012) 48 LWT Food Science and Technology 316.

Bhullar K and Hubbard B “Lifespan and healthspan extension by resveratrol” (2015) 1852 BBA Molecular Basis of Disease 1209.

Choi S-K and others “Suppression of oxidative stress by grape seed and supplementation in rats” (2016) 6 Nutrition Reasearch and Practice 3.

Dolinsky V and Dyck J “Calorie restriction and resveratrol in cardiovascular health and disease” (2011) 1812 BBA Molecular Basis of Disease 1477.

Garavaglia J and others “Grape Seed Oil Compounds: Biological and Chemcial Actions for Health” (2016) 9 Nutrition and Metabolic Insights 59.

Georgiev V and others “Recent Advances and Uses of Grape Falvonoids as Nutraceuticals” (2014) 6 Nutrients 391.

Giovinazzo G and Grieco F “Functional Properties of Grape and Wine Polyphenols” (2015) 70 Plant Foods for Human Nutrition 454.

Halpern G “A celebration of wine: wine IS medicine” (2008) 16 Inflammopharmacology 240.

Kar P and others “Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomised placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin senstitivity” (2009) 26 Diabet Med 526.

Kulkarni S and Cantó C “The molecular target of reversatrol” (2015) 1852 BBA Molecular Basis of Disease 1114.

Leifert W and Abeywardena M “Cardioprotective actions of grape polyphenols” (2008) 28 Nutrition Research 729.

Marques F and others “Resveratrol: Cellular actions of a potent natural chemcial that confers a diversity of health benefits” (2009) 41 The International Journal of Biochemistry and Cell Biology 2125.

Nguyen C and others “Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review” (2017) 9 Nutrients 45.

Nowshehri J and others “Blessings in disguise: Bio-functional benefits of grape seed extracts” (2015) 77 Food Research International 333.

Nunes M and others “Cardioprotective properties of grape seed proanthocyanindins: An update” (2016) 57 Trends in Food Science and Technology 31.

O’Keefe J and others “Alcohol and Cardiovascular Health: The Dose Makes the Poison or the Remedy” 89 Mayo Clinic Proceedings 382.

Panico AM and others “The in vitro effect of a lyophilised extract of wine obtained from Jacquez grapes on human chondrocytes” (2006) 13 Phytomedicine 522. ,

Park E and Pezzuto J “The pharmacology of resveratrol in animals and humans” (2015) 1852 BBA Molecular Basis of Disease 1071.

Pasinetti G and others “Roles of resveratrol and other grape-derive polyphenols in Alzheimer’s disease prevention and treatment” (2015) 1852 BBA Molecular Basis of Disease 1202.

Renaud S and de Lorgeril M “Wine, alcohol, platelets, and the french paradox for coronary heart disease” (1992) 339 Lancet 1523.

Sesso H “Alcohol and Cardiovascular Health” (2012) 1 Amercian Journal of Cardiovascular Drugs 167.

Shrikhande A “Wine by-products with health benefits” (2000) 33 Food Research International 469.

Soleas G and others “Wine as biological fluid: History, production and role in disease prevention” (1997) 11 Journal of Clinical Laboratory Analysis 287.

Teixeira A and others “Natural Bioactive Compounds from Winery By-Products as Health Promoters: A Review” (2014) 15 International Journal of Molecular Sciences 15638.

Tomé-Carneiro J and Visioli F “Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence” (2016) 23 Phytomedicine 1145.

Vingtdeux V and others “Therapeutic potential of resveratrol in Alzheimer’s disease” (2008) 9 BMC Neuroscience S6.

Yu J and Ahmedna M “Functional components of grape pomace: their composition, biological properties and potential applications” (2014) 48 International Journal of Food Science & Technology 221.

Yun Chau Long T “The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling” (2014) 306 AJP Endocrinology and Metabolism 582.

Boswellia

Abdel-Tawab M and others “Boswellia serrata. An overall assessment of In Vitro, preclinical, pharmacokinetic and clinical data” (2012) 50 Pharmacokinetics 349.

Ahmed HH and others “Phytochemical Analysis and Anti-cancer Investigation of Boswellia serrata Biactive Constituents in Vitro” (2015) 16 Asian Pac J Cancer Prev 7179.

Catanzaro D and others “Boswellia serrata preserves intesitnal epithelial barrier from oxidative and inflammatory damage” (2015) 10 PloS ONE.

Grover AK and Samson SE “Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality” (2015) 15 Nutrition Journal.

Ammon HPT and others “Mechanism of anti-inflammatory actions of curcumine and boswellic acids” (1993) 38 Journal of Ethnopharmacology 105.

Kirste S and others “Boswellia serrata acts on cerebal edema in patients irradiated for brain tumors: a prosepctive, randomised, placebo-controlled, double-bline pilot trial” (2011) 117 Cancer 3788.

Moussaieff A and Mechoulam R “Boswellia resin: from religious ceremonies to medical uses; a review of in vitro, in vitro and clinical trials” (2009) 61 Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science 1282.

Ni X and others “Frankincense essential oil prepared from hydrodistillation of Boswellia Sacra gum resins induces human pancreatic cell death in cultures and in a xenograft murine model” (2012) 12 BMC Complementary and Alternative Medicine 253.

Suhail M and others “Boswellia sacra essential oil induces tumor cell specific apoptosis and suppresses tumour agressiveness in cultured human breast cancer cells” (2011) 11 BMC Complementary and Alternative Medicine 10.

Umar S and others “Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis” (2014) 21 Phytomedicine 847.

Zhang Y and others “Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activites and potential species-identifying properties” (2013) 7 Chemistry Central Journal 1.

(2008) 51 Chemical & Engineering News 38.

Olive leaves

Aparicio-Soto, M and others “Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases” (2016) 7 Food and Function 4492.

Azaizeh H and others “Antioxidant activity of phenolic factions in olive mill wastewater” (2012) 134 Food Chemistry 2226.

Barbaro B and others “Effects of the Olive Dervied Polyphenol Oleuropein on Human Health” (2014) 15 International Journal of Molecular Sciences 18508.

Bernardini E and Visioli F “High quality, good health: The case for olive oil” (2017) 119 European Journal of Lipid Science and Technology 6.

Covas M “Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage” (2008) 16 Inflammopharmacology 216.

Estruch R and others “Primary prevention of cardiovascular disease with Mediterranean diet” (2013) 368 N Engl J Med 1279.

Martín Peláez S and others “Health effects of olive oil polyphenols: Recent advances and possibilities for the use of health claims” (2013) 57 Molecular Nutrition and Food Research 760.

Mozaffarian D “Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity – A Comprehensive Review” (2016) 133 Circulation 187.

Omar S “Oleuropein in Olive and its Pharmacological Effects” (2010) 78 Scientia Pharmaceutica 133.

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Bikal Skullcap

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