Based on research 2017-11-24T04:27:15+00:00


Numerous lines of modern research show that heart disease, cancer, and some forms of dementia arise from dysregulated inflammation. From middle age and beyond, changes of natural ageing disturb the inflammatory balance (see Age Better), but lifestyle choices, particularly diet, have a lot to do with how bad it gets. As a consequence, inflammation and food choices are a major theme of contemporary age research.

It takes years to work out how food affects inflammatory diseases, particularly ones that develop slowly. There is usually no single experiment that proves it; scientists build pictures from clues. Population scientists look at what long lived people, from Asia and the Mediterranean, eat. Biochemists explore interactions between food molecules and human metabolism. Other scientists run experiments on animals, and surrogates, like cells, particularly cancerous ones, grown in laboratory dishes. Their findings are regularly discussed in major scientific and medical journals.

These different lines of research consistently show that longevity has a lot to do with eating minimally processed whole food, particularly coloured fruit and vegetables.   Strong leads are emerging that these foods are effective because they contain potent anti-oxidants and anti-inflammatories. However, these molecules are found throughout the natural world, and are not limited to the plant foods we regularly eat. Many of the best ones comes from inedible options, like leaves and roots. Even pips. Even sap.

The implication is that even the healthiest diet, rich in whole plants, can be augmented by natural extracts that rebalance the immune system, and counteract its age-related changes.

LifeGuard Essentials brings you the fruits of this research. It provides a daily supplement of five of the natural world’s most potent inflammation inhibitors, from sources that are not a routine part of the diet.

Inflammation and Ageing

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Heart disease and stroke

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Grape seeds and skin

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Umar S and others “Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis” (2014) 21 Phytomedicine 847.

Zhang Y and others “Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activites and potential species-identifying properties” (2013) 7 Chemistry Central Journal 1.

(2008) 51 Chemical & Engineering News 38.

Olive leaves

Aparicio-Soto, M and others “Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases” (2016) 7 Food and Function 4492.

Azaizeh H and others “Antioxidant activity of phenolic factions in olive mill wastewater” (2012) 134 Food Chemistry 2226.

Barbaro B and others “Effects of the Olive Dervied Polyphenol Oleuropein on Human Health” (2014) 15 International Journal of Molecular Sciences 18508.

Bernardini E and Visioli F “High quality, good health: The case for olive oil” (2017) 119 European Journal of Lipid Science and Technology 6.

Covas M “Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage” (2008) 16 Inflammopharmacology 216.

Estruch R and others “Primary prevention of cardiovascular disease with Mediterranean diet” (2013) 368 N Engl J Med 1279.

Martín Peláez S and others “Health effects of olive oil polyphenols: Recent advances and possibilities for the use of health claims” (2013) 57 Molecular Nutrition and Food Research 760.

Mozaffarian D “Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity – A Comprehensive Review” (2016) 133 Circulation 187.

Omar S “Oleuropein in Olive and its Pharmacological Effects” (2010) 78 Scientia Pharmaceutica 133.

Owen R and others “Identfication of Lignans as Major Components in the Phenolic Fraction of Olive Oil” (2000) 46 Clinical Chemistry 976.

Pelletier A and others “Mediterr anean diet and preserved brain structural connectivity in older subjects” (2015) 11 Alzheimer’s and Dementia 1023.

Pérez Jiménez F “Olive oil and oxidative stress” (2007) 51 Molecular Nutrition and Food Research 1215.

Pitt J and others “Alzheimer’s associated Aβ oligomers show altered structure, immunoreactivity and synatotoxicity with low doeses of oleocanthal” (2009) 240 Toxicology and Applied Pharmacology 189.

Rahmanian N and others “Bioactive profile, dehydration, extraction and application of bioactive components of olive leaves” (2015) 42 Trends in Food Science and Technology 150.

Rigacci S “Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease.” (2105) 863 Adv Exp Med Biol 1.

Scotece M and others “New drugs from ancient natureal foods: Oleocanthal, the natural occuring spicy compound of olive oil” (2015) 20 Drug Discovery Today 406.

Singh B and others “Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer’s Disease: A systematic review and meta-analysis” (2014) 39 Journal of Alzheimer’s Disease 271.

Tresserra-Rimbau A and others “Polyphenol intake and mortality risk: a re analysis of the PREDIMED trial” (2014) 12 BMC Medicine 77.

Bikal Skullcap

Cao Y and others “Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways” (2011) 85 Brain Research Bulletin 396.

Chan E and others “Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats” (2011) 39 The American Journal of Chinese Medicine 693.

Choi J and others “Flavones form Scutellaria baicalensis Georgi attenuate apopotosis and protein oxidation in neuronal cell lines” (2002) 1571 BBA General Subjects 201.
Chi YS and others “Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression” (2003) 66 Biochemical Pharmacology 1271.

Gao L and others “A Bioinofrmatic Approach for the Discovery of Antiaging Effects of Baicalein from Scuterllaria baicalensis Georgi” (2016) Rejuvenation Research 414.

Gao Z and others “Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi” (1999) 1472.BBA General Subjections 643.

Gasiorowski K and others “Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?” (2011) 10 CNS and Neurological Disorders-Drug Targets 184.

Huang WH and others “Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI” (2006) 70 Bioscience, biotechnology and biochemistry 2371.

Kubo M and others “Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix” (1984) 32 Chemcial and pharmaceutical bulletin 2724.

Li BQ and others “The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines” (2000) 49 Immunopharmacology 295.

Li-Weber M “New Therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baiclain” (2009) 35 Cancer Reviews 57.

Moore OA and others “The Extraction, Anticancer effect, Bioavailability and Nanotechnology of Baicalin” (2016) 2 Journal of Nutritional Medicine and Diet Care 11.
Pang K and Zhong Z “Pharmacological effects and pharmacokinetics properties of Radix Acutellariae and its bioactive flavones” (2011) 32 Biopharmaceutics and Drug Disposition 427.

Park B and others “Inhibition of TPA induced cyclooxygenase-2 expression and skin inflammation in mice by woggonin, a plant flavone from Scuterllaria radix” (2001) 425 European Journal of Pharmacology 153.

Polier G and others “Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1” (2011) 2 Cell Death and Disease 182.

Reichek N and Parcham-Azad K “Reperfusion Injury” (2010) 55 Journal of Amercian College of Cardiology 1206.

Wright P “Passport to Peking: A very British mission to Mao’s China.” (2010) 265 Chinese Medicine Lancet 1068.

Wu X and others “Adavances of wogonin, an extract from Scuterllaria baicalensis, for the treatement of multiple tumors” (2016) 9 OncoTargets and Therapy 2936.

Xu Q and others “The quest for modernisation of traditional Chinese Medicine” (2013) 13 BMC Complmentary and Alternative Medicine 132.

Zhang Y and others “Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury” (2006) 108 Journal of ethnopharmacology 355.